Nation-state establishment is a process wherein a country makes an attempt to gain and maintain its autonomy, sovereignty, and independence through the development of its power and institutional capacity. Such a goal can be achieved by gaining territorial saturation, national solidarity and political stability. This process has not reached a successful condition in most West Asian countries, and the governments and for some reasons, the nations do not match properly. An essential reason for these cases relates to the improper creation of these countries and their emergence from Post-World War I treaties, resulting in so many problems and challenges for these countries. The question arising here relates to the problems and challenges that nation-state building process has caused in West Asian countries. The hypothesis of this research involves the fact that various internal and external challenges such as ethnic, religious and racial variations, lack of a stable structure and solidarity of national identity, lack of democratic structures and having no resolution for territorial disputes with neighboring countries, and foreign intervention in the affaires of these countries have caused these problems. Moreover, no inclusive plan and model has been presented to accomplish the process of state-nation building and solving the problems and crises in the region. This research is aimed at providing a general analytical model for explaining the process and the challenges facing the nation-state building process in the region. This is a descriptive-explanatory research whose data are collected by reviewing the documents through library technique.